Healing mechanism of bone allograft

Bone conduction is also the role of scaffolding.,are the blood vessels in the tissue bed around the graft、The process of osteoprogenitor cells invading the interior of a person along the mechanical guidance of the implanted person.Bone conduction is also called bone healing“crawling alternative”,Its earliest in 1893 year Barth Proposed,its theory The core is that the cells of the transplanted bone are all going to die.,Graft bone is replaced by new bone derived from host bone without resorption.With the deepening of research in this area,Axhausen In1907Proposed bone graft in addition to periosteal cells,The remaining cells are necrotic. Healing of bone grafts depends on the host. inner and outer membrane cells of bone,Invasion of bone marrow and surrounding fibrous connective tissue cells,Mesenchymal stem cells turn into osteoclasts first,resorption of bone graft,and then transformed into osteoblasts,Generate new bone,substitute bone graft,make the bone graft heal.Lind and colleagues' studies have found that shifting The allograft at the graft site begins with massive bone resorption.,Then a large number of expressions appear in the cavity after absorptionItype collagen cells,These cells can promote later new bone formation and bone healing.In the case of good local blood supply,From the transplant area around the long man's new Angiogenesis can bring mesenchymal stem cells beside blood vessels,Start of secondary osteogenesis,Necrotic bone is resorbed and replaced by new bone.In this process, the growth of new blood vessels is the core.